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Random Comp Monother Trial of Phenobarb, Phenytoin, Carbamazepine, or Sod Valp for Newly Dx Child Epilep Lancet 347:709-713, deSilva,M.,et al, 1996 See this aricle in Pubmed Article Abstract The overall outcome with all four drugs was good.20%of children remained free of seizures and 73%had achieved 1-year remission by 3 years of followup.We found no significant differences between the drugs for either measures of efficacy at 1,2,or 3 years of followup.The overall frequency of unacceptable side-effects necessitating withdrawal of the randomised drug was 9%.This total included six of the first ten children assigned phenobaritone;no further children were allocated this drug.Of the other three drugs,phenytoin(9%)was more likely to be withdrawn than carbamazepine(4%)or sodium valproate(4%)Our data will inform choice of drug and outcome with four of the standard drugs available for newly diagnosed tonic-clonic or partial seizures with or without secondary generalisation in children.

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